Researchers at The University of Manchester’s have developed a new class of programmable nanofluidic memristors that mimic the memory functions of the human brain, paving the way for next-generation neuromorphic computing.

In a ground-breaking study published in , scientists from the , and the have demonstrated how two-dimensional (2D) nanochannels can be tuned to exhibit all four theoretically predicted types of memristive behaviour, something never before achieved in a single device. This study not only reveals new insights into ionic memory mechanisms but also has the potential to enable emerging applications in low-power ionic logic, neuromorphic components, and adaptive chemical sensing.

Memristors, or memory resistors, are components that adjust their resistance based on past electrical activity, effectively storing a memory of it. While most existing memristors are solid-state devices that rely on electron movement, the team, led by Prof Radha Boya, used confined liquid electrolytes within thin nanochannels made from 2D materials like MoS₂ and hBN. This nanofluidic approach allows for ultra-low energy operation and the ability to emulate biological learning processes.

Four memory modes, one device

The study reveals that by tuning experimental parameters such as electrolyte composition, pH, voltage frequency, and channel geometry, the same nanofluidic device can switch between four distinct memory loop styles, two “crossing” and two “non-crossing” types. These loop styles correspond to different memory mechanisms, including ion-ion interaction, ion-surface charge adsorption/desorption, surface charge inversion, and ion concentration polarisation.

“This is the first time all four memristor types have been observed in a single device,” said , senior author of the study. “It shows the remarkable tunability of nanofluidic systems and their potential to replicate complex brain-like behaviour.”

Mimicking the brain’s synapses

Beyond demonstrating multiple memory modes, the devices also exhibit both short-term and long-term memory, akin to biological synapses. This dynamic control over memory duration is crucial for developing neuromorphic systems that can adapt and learn from their environment.

For instance, the devices could “forget” information over time or retain it for days, depending on the applied voltage and electrolyte conditions, e.g., like how one might quickly forget where they left their keys, yet remember their home address for life.

Imagine you're working in a café. At first, the clatter of cups and chatter is noticeable, but soon your brain filters it out so you can focus. This everyday phenomenon is called sensory adaptation, and short-term synaptic depression is one of the cellular mechanisms contributing to them. The team mimicked short-term synaptic depression, a process where consecutive neural signals reduce the strength of a response unless sufficient time is allowed for recovery. In neurons, this is caused by temporary depletion of neurotransmitter vesicles. In the nanochannels, a similar effect emerges due to the ionic interactions, which requires time to relax back to its initial state.

A minimal model and a major leap

To explain the observed behaviours, the team developed a minimal theoretical model that incorporates ion–ion interactions, surface adsorption, and channel entrance effects. The model successfully reproduces all four memristive loop types, offering a unified framework for understanding and designing future nanofluidic memory systems.

“This work represents a major leap in our understanding of ionic memory,” said Dr Abdulghani Ismail, lead author of the study. “It opens up exciting possibilities for low-power, adaptive computing systems that operate more like the human brain.”

Towards brain-inspired computing

By harnessing the unique properties of 2D materials and fluidic ion transport, the researchers envision a new class of reconfigurable, energy-efficient computing devices capable of real-time learning and decision-making, with broad implications for artificial intelligence, robotics, and bioelectronics.

This research was published in the journal .

Full title: Programmable memristors with two-dimensional nanofluidic channels

DOI: 10.1038/s41467-025-61649-6

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The team introduced a new type of thermal switch utilising high thermal conductivity graphite films. When a voltage is applied, ions insert between graphite layers. These ions disrupt phonon motion, cutting thermal conductivity by up to 1,300%. Removing the voltage expels the ions and restores the original heat-carrying capacity. This powerful modulation allows the device to actively turn heat conduction "on" and "off" at will, mirroring the functionality of electronic transistors, but for heat instead of electricity.

 “What makes our device truly transformative is its ability to operate reliably in extreme environments such as space,” said Dr Pietro Steiner, lead author and current technology lead for graphene-based thermal technologies at , a spinout from the University of Manchester. "The solid-state nature and absence of mechanical parts make it particularly attractive for aerospace applications, where reliability, weight, and efficiency are critical."

Beyond basic switching, the team demonstrated that their device could actively steer heat flow in desired directions. By configuring voltages across patterned electrodes, they created anisotropic thermal conduction pathways, opening possibilities for programmable thermal management systems.

Lead author added, "This thermal switching technology could revolutionise spacecraft thermal regulation, offering dynamic and reconfigurable solutions to manage excess heat without complex moving mechanisms or bulky radiators."

Spacecraft often rely on radiators or mechanical valves to dump excess heat. These systems add weight and risk mechanical failure under vibration. A thin, solid-state switch removes those constraints. It can operate in ultra-high vacuum and tolerate radiation levels found in orbit.

Next, the group will test switching speed under high thermal load. They plan to integrate the switch with prototype electronics. Faster ion motion and alternative intercalants could boost performance further. By directly linking electrical signals to heat transport, this work lays the groundwork for programmable thermal management in aerospace, electronics cooling and adaptive insulation.

This research was published in the journal .

Full title: Electrically controlled heat transport in graphite films via reversible ionic liquid intercalation

DOI: 10.1126/sciadv.adw8588

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Silver has long been used to combat bacteria, particularly in wound care, due to its ability to release ions that disrupt bacterial cells. However, current approaches have limitations; silver can be released too rapidly or unevenly, potentially harming surrounding healthy tissue and resulting in short-lived or inconsistent antibacterial protection.

The Manchester team tackled these issues by designing a graphene oxide-based membrane that can release silver ions slowly and precisely over time. The key lies in the structure of the membrane itself, its nanoscale channels act like filters, regulating how much silver is released.

"Our research represents a paradigm shift in antimicrobial coating technology," states lead author . "By harnessing the potential of graphene oxide membranes, we've unlocked a method for controlled silver ion release, paving the way for sustained antimicrobial efficacy in various applications.”

The team also created a testing model that better reflects real biological conditions. By using foetal bovine serum in lab trials, they could simulate the environment the coating would encounter in the body, offering a clearer view of how it performs over time.

“This approach allows us to deliver just the right amount of silver for extended protection,” first author Dr Swathi Suran adds. “It has potential in many areas, including wound care dressings and antimicrobial coatings for implants, and could bring long-term benefits for both patients and healthcare providers.”

As the team looks ahead, they're focused on exploring how this coating could be integrated into a range of everyday and medical products, making bacterial resistance less of a hidden threat and more of a manageable challenge.

This research was published in the journal .

Full title: Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment

DOI:

The National Graphene Institute (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Following pitches from 14 finalists, the awards brought together innovators, investors, students and supporters to kickstart new innovations with the potential to create significant social and economic impact in the UK and beyond.  

A remarkable 146 students, researchers, academics and recent graduates applied for the prestigious awards. Following a rigorous selection process, six entrepreneurial founders were chosen to receive funding to accelerate their ventures.  

The Ideas with Impact prizes will provide the winners with awards of £100,000, £75,000, and £20,000 to support the critical early stage of their innovation journeys. On the evening, £10,000 was also awarded to the winner of a special 60 second Elevator Pitch Prize, as chosen by the audience. 

The Ideas With Impact 2025 Award winners 

Winner of £100,000:  

• Kay Marshall, Molla Pharm: a novel endometriosis treatment, preventing cells from growing and returning after routine surgery for endometriosis.  

Winners of £75,000:  

• Alexander Stokes, Imprinted Diagnostics: an in-field heart attack diagnostics device, offering rapid lab-quality results from a drop of a blood and without refrigeration.  
• Dan Healy, LanthaGen Bio: engineered bacteria for earth metal extraction from complex mixtures such as mining waste or electronics recycling streams. 

Winners of £20,000 

• Niaz Rayan, SporeSense: an AgriTech device that helps farmers spot invisible disease threats before they can damage crops.  
• Thanasis Stergiuo, HalioGen Power: next generation flow battery, using recyclable materials and avoiding toxic or flammable components.   

Winner of £10,000 Elevator Pitch Prize 

• Parsa Pirhady, Simplex Molecular Ltd: the first at-home DNA test for sexually transmitted infections that gives results immediately, without needing to send samples to a lab.  

Innovation addressing global challenges   

Ideas with Impact is designed to support promising commercial ideas from across our University community. The awards support start-ups that address pressing local and global challenges, ensuring Manchester’s best innovations can move out into the world more quickly, while also creating tangible economic growth. 

In addition to financial support, winners receive access to experienced mentors, networking opportunities, and guidance in translating their research and IP into viable business ventures. 

Donors at the heart of our innovation ecosystem 

The Ideas with Impact Awards are supported by the University’s generous community of donors, who ensure Manchester can continue to support the very best talent at a critical early stage. Philanthropy has already made a huge impact on the University’s innovation ecosystem and will play a vital role as Manchester scales up its ambition to become Europe’s leading innovation university.  

A statement from our judging panel 

 “We are delighted to be able to award the Ideas with Impact funds to a group of budding entrepreneurs who play a critical part in The University of Manchester’s innovation ecosystem. Philanthropy plays a key role in bringing these innovative ideas to life, by supporting founders and helping them to evolve their concepts into high value start-ups and spin-outs.   

Working closely with a community of like-minded donors, business leaders and industry partners enables us to create high value impact, both socially and economically. We are delighted to congratulate our winners and, for all our other finalists and applicants, do not be disheartened! We are building a growing and supportive network through the Innovation Academy to help your amazing ideas get to their next milestone, and we can’t wait to work with you all.”   

• Dr Cat Headley, CEO of The University of Manchester Innovation Factory 
• John Holden, Associate Vice-President for Major Special Projects at The University of Manchester. 
• Professor Aline Miller, Director of the Innovation Academy and Chief Scientific Officer of Unit M at The University of Manchester. 

Philanthropic Support  

Interested in supporting brilliant future founders and ensuring entrepreneurship for all? We’d love to explore opportunities with you. Contact Olympia Kennard, Head of Philanthropy, Research & Innovation, to begin a conversation: [Olympia.Kennard@manchester.ac.uk](mailto:Olympia.Kennard@manchester.ac.uk). 

Our innovation ecosystem 

• Read more about Unit M here:   
• Read more about the Innovation Factory here:    
• Read more about the Masood Entrepreneurship Centre here:   

The PDER was coordinated by the Policy Profession Unit, prepared for publication in the Department for Work and Pensions, and launched by the Cabinet Office with support from the University of the Arts London. 

The report represents a true cross-sector effort to rethink how government can better serve the public. Professor Richardson’s involvement highlights how academic research can directly shape public services, and help to build more responsive, trusted and inclusive government.

The manufacturing of African print textiles has shifted to China in the 21st century. While they are widely consumed in African countries – and symbolic of the continent – the rise of “made in China” has undermined the African women traders who have long shaped the retail and distribution of this cloth.

For many decades , the Dutch textile group which traces its origins to 1846 and whose products had been supplied to west Africa by European trading houses since the late 19th century, dominated manufacture of the cloth. But in the last 25 years dozens of factories in China have begun to supply African print textiles to west African markets. Qingdao Phoenix Hitarget Ltd, Sanhe Linqing Textile Group and Waxhaux Ltd are among the best known.

We conducted to establish how the rise of Chinese-made cloth has affected the African print textiles trade. We focused on Togo. Though it’s a tiny country with a population of , the capital city, Lomé, is the trading hub in west Africa for the textiles.

We conducted over 100 interviews with traders, street sellers, port agents or brokers, government officials and representatives of manufacturing companies to learn about how their activities have changed.

“Made in China” African print textiles are substantially cheaper and more accessible to a wider population than Vlisco fabric. Our market observations in Lomé’s famous Assigamé market found that Chinese African print textiles cost about 9,000 CFA (US$16) for six yards – one complete outfit. Wax Hollandais (50,000 CFA or US$87) cost over five times more.

Data is hard to come by, but our estimates suggest that 90% of imports of these textiles to Lomé port in 2019 came from China.

One Togolese trader summed up the attraction: “Who could resist a cloth that looked similar, but that cost much less than real Vlisco?”

Our research shows how the rise of China manufactured cloth has undermined Vlisco’s once dominant market share as well as the monopoly on the trade of Dutch African print textiles that Togolese traders once enjoyed.

The traders, known as Nana-Benz because of the expensive cars they drove, once enjoyed an economic and political significance disproportionate to their small numbers. Their political influence was such that they were key backers of Togo’s first – himself a former director of the United Africa Company, which distributed Dutch cloth.

In turn, Olympio and long-term leader General Gnassingbé Eyadéma provided policy favours – such as low taxes – to support trading activity. In the 1970s, African print textile trade was considered as significant as the phosphate industry – .

Nana-Benz have since been displaced – their numbers falling from 50 to about 20. Newer Togolese traders – known as Nanettes or “little Nanas” – have taken their place. While they have carved out a niche in mediating the textiles trade with China, they have lower economic and political stature. In turn, they too are increasingly threatened by Chinese competition, more recently within trading and distribution as well.

China displaces the Dutch

Dating back to the colonial period, African women traders have played essential roles in the wholesale and distribution of Dutch cloth in west African markets. As many countries in the region attained independence from the 1950s onwards, Grand Marché – or Assigamé – in Lomé became the hub for African print textile trade.

While neighbouring countries such as Ghana limited imports as part of efforts to promote domestic industrialisation, Togolese traders secured favourable conditions. These included low taxes and use of the port.

Togolese women traders knew the taste of predominantly female, west African customers better than their mostly male, Dutch designers. The Nana-Benz were brought into the African print textile production and design process, selecting patterns and giving names to designs they knew would sell.

They acquired such wealth from this trade that they earned the Nana-Benz nickname from the cars they purchased and which they used to collect and move merchandise.

Nana-Benz exclusivity of trading and retailing of African print textiles cloth in west African markets has been disrupted. As Vlisco has responded to falling revenues – over 30% in the first five years of the 21st century – due to its Chinese competition, Togolese traders’ role in the supply chain of Dutch cloth has been downgraded.

In response to the flood of Chinese imports, the Dutch manufacturer re-positioned itself as a luxury fashion brand and placed greater focus on the marketing and distribution of the textiles.

Vlisco has opened several boutique stores in west and central Africa, starting with Cotonou (2008), Lomé (2008) and Abidjan (2009). The surviving Nana-Benz – an estimated 20 of the original 50 – operate under contract as retailers rather than traders and must follow strict rules of sale and pricing.

While newer Togolese traders known as Nanettes are involved in the sourcing of textiles from China, they have lower economic and political stature. Up to 60 are involved in the trade.

Former street sellers of textiles and other petty commodities, Nanettes began travelling to China in the early to mid-2000s to source African print textiles. They are involved in commissioning and advising on the manufacturing of African print textiles in China and the distribution in Africa.

While many Nanettes order the common Chinese brands, some own and market their own. These include what are now well-known designs in Lomé and west Africa such as “Femme de Caractère”, “Binta”, “Prestige”, “Rebecca Wax”, “GMG” and “Homeland”.

Compared to their Nana-Benz predecessors, the Nanettes carve out their business from the smaller pie available from the sale of cheaper Chinese cloth. Though the volumes traded are large, the margins are smaller due to the much lower final retail price compared to Dutch cloth.

After procuring African print textiles from China, Nanettes sell wholesale to independent local traders or “sellers” as well as traders from neighbouring countries. These sellers in turn break down the bulk they have purchased and sell it in smaller quantities to independent street vendors.

All African print textiles from China arrive in west Africa as an incomplete product – as six-yard or 12-yard segments of cloth, not as finished garments. Local tailors and seamstresses then make clothes according to consumer taste. Some fashion designers have also opened shops where they sell prêt-à-porter (ready-to-wear) garments made from bolts of African print and tailored to local taste. Thus, even though the monopoly of the Nana-Benz has been eroded, value is still added and captured locally.

Since the COVID-19 pandemic, Chinese actors have become more involved in trading activity – and not just manufacturing. The further evolution of Chinese presence risks an even greater marginalisation of locals, already excluded from manufacturing, from the trading and distribution end of the value chain. Maintaining their role – tailoring products to local culture and trends and linking the formal and informal economy – is vital not just for Togolese traders, but also the wider economy.

, Reader, Global Development Institute, and , Postdoctoral fellow, Duke Africa Initiative,

This article is republished from under a Creative Commons license. Read the .

Approximately one in 50 people will develop wounds that fail to heal with the issue a particular problem for older people and in diabetes. 

Chronic wounds are more likely to become infected and can even result in a need for amputation making tackling them a really important issue. 

The paper published in the , reveals that the enzyme-  called arginase 1 -  can  promote wound repair in the  skin, through modulation of  a protein called Lipocalin2. 

A major factor in non-healing wounds is a failure of the damaged outer layer of skin, the epidermis, to repair and regrow. This can be worsened by uncontrolled inflammation and infection. 

The authors show that on wounding Arginase 1 enhanced production of Lipocalin2, an anti-microbial agent, which was required to combat infection and help the skin cells reform the skin barrier. 

Arginase 1 also reduced levels of inflammatory products made by the damaged skin cells showing its potential for tackling the inflammation typically associated with chronic wounds.

 The researchers also showed that the function of arginase, could be restored to help skin regrow by adding products that arginase 1 can make which include metabolites called polyamines. 

The paper follows on from previous by the team, published in February, which showed how important this enzyme Arginase 1 was for healthy skin and eczema. 

A healthy skin barrier involves a balance between cells multiplying (‘proliferating’) and changing their function (‘differentiating’). A key feature of eczema is a disruption of this balance. Arginase is required for skin barrier regulation where it functions to promote cell differentiation, a process essential to maintain a protective healthy skin barrier. A process that is disrupted in eczema.

 Arginase 1 has been shown to have an important role in tissue repair but how it promotes skin health was until now, unknown. 

Lead author Sheena Cruickshank, Professor of immunology at The University of Manchester ‘s Lydia Becker Institute of Immunology and Inflammation, said: “These two studies highlight the mechanism by which arginase 1 promotes barrier function and ensures good wound healing. 

“It’s importance is highlighted by the abnormal levels of Arginase seen in wounds that don’t heal well and eczema 

“That is why we think that targeting arginase 1 has potential to be used in the treatment of eczema and non-healing skin ulcers. Data in the two papers suggest it might also protect the skin from infection.” 

She added: “Non-healing skin wounds, or ulcers, are incredibly common and serious skin conditions that are more common as we age. 

“They can have a devastating effect on the lives of patients, causing chronic pain, problems with mobility and can lead to increased morbidity. 

“Similarly, eczema can significantly impact quality of life, leading to intense itching, pain, and sleep disruption. It can also increase the risk of skin infections. 

“We clearly have a long way to go before these skin conditions can be cured, but knowing the crucial role of arginase 1 in the healing process and that we can rescue function in model systems is an important milestone.” 

Jason Wong, Professor of Reconstructive Plastic Surgery and Regenerative Medicine  from The University of Manchester said: “The burden of chronic wounds seems to be on the increase and any new insights to how we can treat the problem will save limbs.” 

The PhD studentship for coauthor Denis Szondi was funded by the Agency for Science, Technology and Research (A*STAR) Singapore and The University of Manchester. 

The Biotechnology and Biological Sciences Research Council (BBSRC) funded a PhD studentship for co-author Rachel Crompton. 

Banked tissue collection was funded by Wellcome Institutional Strategic Support Fund and supported by the National Institute for Health and Care Research (NIHR)Manchester Biomedical Research Centre (BRC). (Prof Wong is part of the Dermatology Theme at the NIHR Manchester BRC.

British Journal of Dermatology, Volume 193, Issue 1, July 2025, Pages 125–135, 

The publication includes detailed chapters on iconic buildings such as Whitworth Hall, the John Rylands Library and Jodrell Bank’s Lovell telescope, as well as little known aspects of campus history including lost rivers, nuclear reactors, Toblerone-shaped halls of residences and unrealised plans for an underground station.

The book particularly highlights the architectural significance of Owens College, and how its Gothic Revival buildings designed by Alfred Waterhouse established a distinct identity in Victorian Manchester. These early structures set a tone of civic ambition and intellectual seriousness that still echoes through the campus today.

A dedicated section also explores the post-war expansion of science and engineering facilities at the University, driven by Cold War priorities and rising student numbers. It examines the rapid, often pragmatic construction of labs and lecture theatres, many of which defined the university’s mid-20th-century landscape.

“This book offers the public a chance to see behind the scenes - to understand why buildings were built the way they were, and how the campus continues to evolve to meet the needs of students, researchers and the wider city,” added Dr Hopkins.

The publication was made possible through the generous support of both internal and external partners. Within the University, from the School of Environment, Education and Development and the University of Manchester Library. Additional support was provided by companies that have worked closely on building projects across the campus over the years, including Avison Young, Arcadis, Balfour Beatty, BDP, CBRE, Halliday Meecham Architects, Recom Solutions, Rider Levett Bucknall, and Sheppard Robson.

Building Towards the Bicentenary is available to view for free .

Professor Devinney joins other Manchester-based Fellows including Professors James Nazroo, Melanie Giles and Penny Harvey, who have all been elected to the British Academy in recent years reflecting the University’s enduring commitment to cutting-edge scholarship and societal impact.

President of the British Academy Professor Susan J. Smith said: “One of my first acts as incoming President is to welcome this year’s newly elected Fellows, who represent the very best of the humanities and social sciences. They bring years of experience, evidence-based arguments and innovative thinking to the profound challenges of our age.”

“Every new Fellow enlarges our capacity to interpret the past, understand the present, and shape resilient, sustainable futures. It is a privilege to extend my warmest congratulations to them all.”

The team uncovered a rare type of wave, known as a shear phonon polariton, in a two-dimensional form of the material. Phonon polaritons are light-matter hybrid waves that emerge when light interacts with atomic vibrations in certain crystals. They can travel through materials in unusual ways and concentrate light into extremely small volumes.

In this study, the researchers found that in  thin films of gypsum, these waves undergo a topological transition, shifting from hyperbolic to elliptical behaviour, passing through a unique canalized state.

This transition allows scientists to tune how light propagates through the material.

“The studies of shear phonon polaritons in previous studies were limited to bulk crystals in the hyperbolic regime. In our study we aimed to complement those initial findings with shear polaritons in a 2-dimentional material,” said Dr Pablo Díaz Núñez, who co-led the study. “And remarkably, we discovered that shear phonon polaritons in gypsum support a topological transition from hyperbolic to elliptical propagation, with canalization in between.”

Dr Díaz Núñez added, “Moreover, we were able to confine light to a space twenty-five times smaller than its wavelength and slow it down to just a fraction of its speed in vacuum, this opens up new possibilities for manipulating light at the nanoscale.”

The research also highlights the role of crystal symmetry. Gypsum belongs to a class of materials with low symmetry, specifically to the monoclinic crystal system, which gives rise to asymmetric light propagation and energy loss, the central characteristic of shear polaritons.

These findings extend beyond fundamental research of phonon polariton propagation and could support future developments in areas that rely on precise control of light, such as thermal management, sensing, and imaging beyond the limits of conventional optics. Moreover, the study introduces gypsum as a new platform for exploring advanced photonic concepts in emerging areas like non-Hermitian photonics.

This research was published in the journal .

Full title: Visualization of topological shear polaritons in gypsum thin films

DOI:

The National Graphene Institute (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester also commented: “Lord Alliance was a close friend to the University and a remarkable figure whose contributions extended far beyond it. His belief in the transformative power of education created opportunities for generations of students, while his leadership and philanthropy shaped the Alliance Manchester Business School and the wider Manchester region. His story will remain a source of inspiration for years to come, and his legacy will endure in the lives he touched and the institutions he helped to build.”

On Thursday 17^th July 2025, researchers from The University of Manchester furthered their entrepreneurial journey by completing the MEC R2I programme at the Options Roundabout event. The event saw participants pitch their innovations to a panel of commercialisation experts, entrepreneurs and funders from across the University. The day concluded with a celebration of the cohort’s accomplishments with peers and supporters of the programme, as well as a networking opportunity to aid them in their next steps.

The R2I programme aims to inspire and accelerate the translation of academic research into impact-driven ventures. Over the course of 12-weeks, participants benefited from a series of bespoke workshops and mentoring opportunities to help them articulate their ideas and explore the commercial potential of their research.

Six Innovation Enabling Awards were granted to acknowledge the progress and growth potential, with early career researchers receiving between £2,000 to £10,000 to support the further development of their businesses.

Aurore Hochard, Director of the Masood Entrepreneurship Centre, presented the Innovation Enabling Awards to the six winning projects.

Award Winners

Innovation Enabling Award: £10,000

Lutèo Medical

Dr Abigail Elias (School of Biological Sciences)

“The support, mentoring, and resources provided through the Researcher to Innovator (R2I) programme have been transformative. Most importantly, the experience gave me the confidence to reach out to potential stakeholders and begin building the connections needed to bring my ideas to life. It was also great to connect with people on the cohort from such a broad range of disciplines."

Innovation Enabling Award: £5,000

ViRTUE: Virtual Reality Training in Ultrasonic Evaluation

Daniel Conniffe (School of Engineering)

“R2I equipped me with the resources, motivation, and communication skills to bridge the gap between research and industry. Through building a strong network, I gained insight into real-world challenges and was able to pivot my research toward creating a meaningful, practical solution.”

Innovation Enabling Award: £3,000

Hollowgraf

Dr Premlal Balakrishna Pillai (School of Engineering)

“The encouragement, guidance, and practical knowledge I gained through R2I have been truly inspiring. The programme really helped me to clarify my idea and shape it into a commercially viable opportunity, giving me the confidence to take the first steps into entrepreneurship.”

Innovation Enabling Award: £2,000

PRECIOUS: Programmable Recovery of Critical Elements Using Synthetic Biology

Dr Sergio Gutiérrez Zapata (School of Natural Sciences)

“The R2I programme gave me the push I didn’t know I needed. It helped me go from a scientific idea to something that could actually work in the real world — with real people and real challenges. Being able to shape a venture around bioremediation, and test the idea from different angles, has been incredibly motivating.”

Innovation Enabling Award: £2,000

PRISM: Prostate cancer Risk Identification by Spectroscopic Measurement

Dr Dougal Ferguson (School of Engineering)

“The R2I programme really helped me hone my ability to concisely and impactfully pitch my research as a commercial application. I am much more confident now pitching my science to a non-scientific audience!”

Innovation Enabling Award: £2,000

Inclusive Skincare Solutions

Yoana Kirilova (School of Biological Sciences)

“The Researcher to Innovator programme has been a fantastic journey – connecting with like-minded peers, learning from experienced entrepreneurs, and gaining insights that will continue to shape my innovation journey.”

The prize winners will also receive expert support and signposting to regional and national accelerator programmes and all the participants on the MEC R2I programme will be connected to the wider ecosystem for further support, mentoring and guidance in taking their research ideas forward.

The organisers wish to thank the Innovation Academy and the Engineers for Business Fellowship for their sponsorship of the Innovation Enabling Awards.

The  is supported by the University’s Innovation Academy. The Innovation Academy is a pan University initiative and joint venture between the , the  and the Business Engagement and Knowledge Exchange team, bringing together knowledge, expertise and routes to facilitate the commercialisation of research.

The study, led by ETH Zurich and supported by The University of Manchester, sheds new light on how fast-moving mixtures of water, soil and rocks – known as debris flows – develop into a series of surges, destroying everything in their path. 

Using highly sensitive 3D laser scanners, the scientists collected measurements during a major debris flow in the Illgraben valley in Switzerland on 5 June 2022. Analysis enabled the scientists to pinpoint how small surface disturbances evolve down the channel into powerful large amplitude waves that concentrate the flow’s destructive power.

The findings, published in the journal , are among the most detailed measurements of a real-life debris flow ever recorded.

Debris flows are a recurring natural hazard in steep terrain throughout the world, and are triggered by heavy rainfall, and increasingly, glacial runoff and permafrost melt. Recent landslides in the Alps continue to highlight the risks posed by debris flows, such as the 2017 Bondo landslide in Graubünden, which triggered a debris flow that travelled 4km downhill into the Bondasca Valley. This emphasises the urgent need to better understand and predict these hazardous events.

Due to the frequency of debris flow occurence, the Illgraben valley has been equipped with measuring instruments since 2000. It has recently supplemented by five highly sensitive 3D laser scanners, called LiDAR, which can determine distance and speed, and six high-speed video cameras.

On the day of the June 2022 event, 25,000 cubic meters of water, earth and debris poured approximately seven kilometres down the bed of the Illbach before the muddy stream was absorbed by the river Rhône at Susten. The devices measured surface velocities and the evolving free surface of the debris flow at three measuring stations with a spatial resolution of 2 cm and a temporal resolution of 0.1 seconds.

The team of scientists from ETH Zurich, Swiss Federal Institute for Forest, Snow and Landscape Research (Birmensdorf) and The University of Manchester, were able to document how the waves grew along the channel and use the data to develop a new friction law that was used in a debris-flow model to realistically simulate the  genesis and growth of the waves.

They found that near the top of the (about 2km from the outflow into the Rhône river), the debris flow had a fast-moving wave front, but no surges, while further down the channel the flow became shallower and spontaneously developed a series of waves. During the 30-minute event, researchers recorded 70 of these surges, which emerge from a surface instability that allows the waves to grow and as they move downhill.

Lead researcher, Jordan Aaron, Professor of Engineering Geology at ETH Zurich, said: "It has long been known that waves play a central role in the destructive power of debris flows, because they concentrate the forces that are applied to structures in their path.

"Thanks to the measurements around the debris flow of June 2022 and the modelling based on them, the researchers now have a better understanding. Our analysis provides new insights into the dynamics of debris flows and enables improved hazard management in the medium term.”

This research, which was partially funded by the UK’s Natural Environment Research Council (), has been published in the journal Communication Earth & Environment

Full title: Detailed observations reveal the genesis and dynamics of destructive debris-flow surges

DOI: doi.org/10.1038/s43247-025-02488-7

Link:  https://www.nature.com/articles/s43247-025-02488-7

The research study was funded by the National Institute for Health and Care Research (NIHR), LifeArc and the Wellcome Trust and published in The Lancet Neurology today (16/07/25). 

Twenty-five years ago when Timothy Bingham was two years old, he had a mild flu like illness which left him unable to walk. 

Three years later following another infection, he was paralysed and has been in a wheelchair ever since. 

Then in 2011, doctors saw an 8-month-old girl at a UK hospital who had been completely fit and well until a mild chest infection left her unable to breathe without the support of a ventilator. 

They considered that there may be a genetic cause as her two brothers had experienced similar severe problems following mild infections. 

Genetic researchers at the University of Manchester have now discovered that changes in a gene called RCC1 led to this severe nerve damage in both Timothy and the family in Manchester. 

A further 20 children from 10 families from the UK, Türkiye, Czechia, Germany, Iran, India, Saudi Arabia, Cyprus, and Slovakia have been found to have changes in the same gene leading to this severe nerve condition all triggered by mild infections. 

In over half of the children, doctors suspected the diagnosis of a different severe nerve condition that can develop after infection called . 

The researchers performed laboratory studies on skin cells taken from patients and in specially genetically  engineered fruit flies to show that the damage to nerves can be caused by certain chemicals. 

Skin cells from patients when looked at under special microscopes have changes very similar to those seen in the cells of patients with motor neuron disease where muscles, including those controlling breathing and swallowing, become weak. 

Bill Newman, Professor of Translational Genomic Medicine at the University of Manchester and Rare Condition co-theme lead at the NIHR Manchester Biomedical Research Centre led the research. 

He said: “Until this study, little was known about why some people experience severe nerve damage after they have had a mild infection like flu or a stomach upset. 

“This work provides families with an explanation and is the first step in us developing an effective treatment. As children are well before they develop nerve damage following an infection, this gives us an opportunity to treat at risk children before problems occur. 

“The similarity with Guillain-Barré syndrome and with conditions like motor neuron disease may help us understand these more common conditions and why some people are at greater risk and what treatments may be effective.” 

Kate Bingham, mum of Tim who is now 28, said: “About 25 years ago Tim got a flu like infection and a temperature. What seemed like a minor illness had devastating consequences. 

“The attack, and subsequent attacks - did terrible damage. First to his legs, then his arms, his face and his chest. 

“And now he needs 24-hour care. His diaphragm barely works at all so he can’t cough. It’s hard for him to chew and he can’t drink unassisted. He can’t move in bed so needs turning throughout the night. The things we all take for granted he can’t do. 

“But I’m proud of how strong Tim has been. He now has a girlfriend he met online who is wonderful. He proves there is life beyond disability.” 

She added: “As Tim’s mum the discovery of a gene which is linked to what happened to Tim means everything to me. For so long we have lived with uncertainty of not knowing the full picture. 

“This breakthrough brings us great hope as it will do to all those people who have waited years for answers. This is something that helps us look to the future.” 

Sam Barrell, CEO of LifeArc, said, ““For many people living with rare conditions, the wait for a diagnosis can be agonisingly long - around a third wait more than five years. In Timothy’s case, that uncertainty stretched for over twenty years.  This discovery provides a potential target for treatment and the first step towards delivering a brighter future for people that could be living with this same devastating condition.” 

Image: Kate and Tim and Tim with his dog, Red.

The paper Acute-onset axonal neuropathy following infection in children with biallelic RCC1 variants: a case series is published in The Lancet Neurology here DOI 

The research, published today in , investigates a meter-long flipper from a Temnodontosaurus - a giant ichthyosaur – with uniquely preserved with fossilised soft tissues.

The findings reveal that the marine reptile, which exceeds 10m in length, was equipped with evolved to have specialised fins that the scientists believe served to suppress the sound of its own movements when foraging in dimly lit environments about 183 million years ago - an evolutionary adaptation never previously seen in any aquatic creature, living or extinct.

The team involves an international team of scientists, led by Dr Johan Lindgren from Lund University in Sweden, in collaboration with one of the world’s leading ichthyosaur experts, , a Palaeontologist at The University of Manchester, who has been working on the fossil for about six years and says the finding “represents one of the greatest fossil discoveries ever made”  and could revolutionise the way scientists investigate other prehistoric animals.

Dr Lindgren, who has pioneered research on ancient marine reptile soft tissues, said: “The wing-like shape of the flipper, together with the lack of bones in the distal end and distinctly serrated trailing edge collectively indicate that this massive animal had evolved means to minimise sound production during swimming. Accordingly, this ichthyosaur must have moved almost silently through the water, in a manner similar to how living owls—whose wing feathers also form a zigzag pattern—fly quietly when hunting at night. We have never seen such elaborate evolutionary adaptations in a marine animal before.”

Although many small ichthyosaurs have been found with soft-tissue preservation, scientists have never found anything on this scale.

Using a range of advanced imaging, chemical analysis and computational modelling techniques, the researchers also identified that the structure of the flippers were truly unique, with scalloped trailing edge reinforced by mineralised, rod-like structures that the team name ‘chondroderms’. 

Moreover, Temnodontosaurus also had the largest eyes – the size of footballs – of any vertebrate known, supporting the hypothesis that this aquatic reptile hunted under low-light conditions, either at night or in deep waters. 

Dr Dean Lomax, who is also an 1851 Research Fellow at the University of Bristol, said: “The first time I saw the specimen, I knew it was unique. Having examined thousands of ichthyosaurs, I had never seen anything quite like it. This discovery will revolutionise the way we look at and reconstruct ichthyosaurs (and possibly also other ancient marine reptiles) but specifically soft-tissue structures in prehistoric animals.”

 The fossilised flipper was discovered by fossil collector Georg Göltz, a co-author on the new study. Remarkably, Georg made the find entirely by chance whilst looking for fossils at a temporary exposure at a road cutting in the municipality of Dotternhausen, Germany.

The fossil consists of both the part and counterpart (opposing sides) of almost an entire front flipper. Although Georg looked for more, no other remains were found. As the top part of the fin is missing, the team surmise that it was originally an isolated flipper that might have been ripped off by a larger ichthyosaur.

Georg brought the specimen to the attention of palaeontologist and co-author Sven Sachs of the Natural History Museum, Bielefeld, who recognised the rarity of the find.

Dr Lindgren said: “The fact that we are able to reconstruct the stealth capabilities of a long-extinct animal is quite remarkable. Also, because human-induced noise from shipping activity, military sonar, seismic surveys, and offshore wind farms has a negative impact on today’s aquatic life, our findings could provide inspiration to help limit the adverse biological effects from anthropogenic input to the modern marine soundscape.”

 To unravel the mystery behind the features preserved in this fossil, it was subjected to a range of sensitive imaging, elemental and molecular analyses. The multidisciplinary research team included palaeontologists, engineers, biologists and physicists. This involved high-end techniques such as synchrotron radiation-based X-ray microtomography at the Swiss Light Source SLS at PSI and Diamond Light Source, time-of-flight secondary ion mass spectrometry and infrared microspectroscopy, along with the reconstruction of a virtual model using computational fluid dynamics.

Dr Lomax added: “The fossil provides new information on the flipper soft tissues of this enormous leviathan, has structures never seen in any animal, and reveals a unique hunting strategy (thus providing evidence of its behaviour), all combined with the fact that its noise-reducing features may even help us to reduce human-made noise pollution. Although I might be a little bias, in my opinion, this represents one of the greatest fossil discoveries ever made.”

The very first ichthyosaur brought to the attention of science was discovered over 200 years ago by pioneering palaeontologist Mary Anning and her brother Joseph. That fossil was also a Temnodontosaurus, the same type of ichthyosaur to which this flipper belonged.

“In a weird way, I feel that there is a wonderful full-circle moment that goes back to Mary Anning showcasing that even after 200 years, we are still uncovering exciting and surprising finds that link back to her initial discoveries”, added Dr Lomax.

Nature article reference: Lindgren, J., Lomax, D. R., Szász, R-Z., Marx, M., Revstedt, J., Göltz, G., Sachs, S., De La Garza, R. G., Heingård, M., Jarenmark, M., Ydström, K., Sjövall, P., Osbæck, F., Hall, S. A., de Beeck, M. O., Eriksson, M. E., Alwmark, C., Marone, F., Liptak, A., Atwood, R., Burca, G., Uvdal, P., Persson, P. and Nilsson, D-E. 2025. Adaptations for stealth in the wing-like flippers of a large ichthyosaur. Nature, 10.1038/s41586-025-09271-w.

Link to paper:

Up to £50 million is to be invested in a Medical Research Council Centre of Research Excellence (MRC CoRE) in Exposome Immunology over the next 14 years.

These environmental exposures, which also include things like microbes and toxins, predominantly interact with our bodies at what we call ‘mucosal barrier sites’, for example our lungs and intestines. Here, they met by our immune cells, and can change how the immune system works, pushing some tissues into chronic inflammation, causing diseases such as asthma, chronic obstructive pulmonary disorder (COPD) and inflammatory bowel disease (IBD).

The centre will embrace AI technology to interrogate large data sets, such as those from UK Biobank, patient cohorts and long-term studies in hospital clinics, and identify common pathways by which environmental factors disrupt the immune system. Findings will be tested through laboratory studies and by exposing healthy volunteers to pollutants and common viral infections, leading to more accurate diagnoses, better prevention, and more effective treatment options.

Individuals from disadvantaged socioeconomic backgrounds often have a more adverse exposome, facing greater exposure to pollution, mould (in poor quality housing), and occupational hazards (cleaning chemicals, industrial processes). The MRC CoRE is therefore key to The University of Manchester’s mission to address , and builds on work investigating .

Professor Judi Allen, from The University of Manchester is Director of the MRC CoRE in Exposome Immunology.

She said: “Globally we’re facing a crisis in chronic inflammatory diseases, such as asthma and inflammatory bowel disease. For decades we’ve been studying how our genes make us susceptible to disease. While very valuable, genetics has only got us so far. We need to understand how our environment interacts with our genes to make our immune system malfunction.”

“We will benefit from advances in new technologies to identify which of the many complex factors may be important in driving disease, but what’s different about our new Centre is we are going to define how the immune system is altered by these environmental factors and how that impacts inflammation. Changing environments, often made worse by socioeconomic disparities and rising pollution, appear to be increasing the rates of these diseases, making it even more imperative to find the causes.”

“We hope to later expand our research to include more environmental factors, such as mould and microplastics, which are growing concerns. An ultimate goal of this research would be to discover the underlying causes of these chronic diseases so we can develop better prevention and treatments.”

Professor Fiona Powrie, co-director of the MRC CoRE in Exposome Immunology, from University of Oxford, said: “This is an exciting opportunity to bring together complementary expertise in The University of Manchester and University of Oxford to build a multidisciplinary team to tackle this challenge. Our Centre will train a new generation of scientists working across biology and environmental science, future proofing our efforts to combat the health effects of a changing environment.”

Professor Patrick Chinnery, MRC Executive Chair, said: “This new MRC Centre of Research Excellence will transform our understanding of how lifelong environmental exposures shape immune health and cause chronic inflammatory diseases. With chronic inflammatory diseases posing such a large and growing disease burden, the new centre is well placed pave the way for more effective and targeted treatments.

“Alongside exceptional scientific leadership linking two world-leading centres, and strong partnerships with patients and digital health innovators, the scientists’ commitment to the next generation of researchers will embed UK leadership in this field, with long-term potential to deliver a transformative, global impact for health.”

The research, published today in the journal, , demonstrates that compounds or ‘volatiles’ found in sebum — the oily substance produced by our skin —hold key biomarkers for identifying Parkinson’s in its earliest stages.

Using a technique known as Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS), scientists at The University of Manchester, in collaboration with Salford Royal NHS Trust and the Medical University of Innsbruck, analysed skin swabs from participants with Parkinson’s, healthy volunteers, and those with a sleep disorder called isolated REM Sleep Behaviour Disorder (iRBD) — a known early warning sign of Parkinson’s disease.

The results showed that people with iRBD had distinct chemical profiles in their sebum that were different from healthy individuals, but not yet as pronounced as those with established Parkinson’s disease. This supports the idea that Parkinson’s disease leaves a detectable trace on the body well before physical symptoms appear.

Joy Milne – the ‘super smeller’ who inspired the research  –  was also able to distinguish swabs from people with iRBD from the control group and Parkinson’s patients. Intriguingly, she was able to detect both diseases in two of the swabs that came from iRBD individuals, who were later diagnosed with Parkinson’s at their next clinical appointment, after sampling.

Professor Perdita Barran, Professor of Mass Spectrometry at The University of Manchester, said: “This is the first study to demonstrate a molecular diagnostic method for Parkinson’s disease at the prodromal or early stage. It brings us one step closer to a future where a simple, non-invasive skin swab could help identify people at risk before symptoms arise allowing for earlier intervention and improved outcomes.”

The study involved more than 80 participants, including 46 people with Parkinson’s, 28 healthy controls, and nine with iRBD.  They found 55 significant features in the sebum that varied between the groups. Those with iRBD often showed levels that sat between the healthy controls and the Parkinson’s group, reinforcing the possibility of detecting the disease in its early phase.

Dr Drupad Trivedi, a researcher from The University of Manchester, built a model that examined the markers in a longitudinal sampling study. He collected samples from Parkinson’s patients over a three-year period and found patterns that suggest this method can also be used to map the progression of the disease, which could have use in refining treatment options and improve patient outcomes.

Sebum is also easy to collect using gauze swabs from the face or upper back, making it ideal for non-invasive routine screening and regular monitoring. by the team has also shown it does not need to be stored in the same cold conditions as other biofluids, such as blood, reducing associated costs.

The research is inspired by the observations of Joy Milne, who detected a unique scent in individuals with Parkinson's disease, prompting researchers at The University of Manchester to explore sebum as a source of diagnostic biomarkers.

By using mass spectrometry, a technique that measures the weight of molecules, they have found that there are distinctive Parkinson’s markers in sebum, which has led them to develop this non-invasive swab test.

These findings have recently been validated in another paper, published today in the, where trained dogs were able to detect Parkinson’s in the patients recruited by Prof Barren and Dr Trivedi with remarkable accuracy by smelling skin swabs.

Now, the researchers are continuing to develop and improve the sebum-based testing to eventually use as a practical tool in real-world clinical settings.

Dr Drupad Trivedi, Lecturer in Analytical Measurement Sciences at The University of Manchester, said: "Our goal is to develop a reliable, non-invasive test that helps doctors detect Parkinson’s earlier, track its progression, and ultimately improve patient outcomes.

“We’re also keen to hear from other hyperosmic individuals, potential ‘super smellers’ like Joy, whose remarkable sense of smell could help extend our work to detect other diseases with potential odour signatures."

***

This research was published in the journal npj Parkinson's Disease

Full title: Classification of Parkinson’s Disease and idopathic REM Sleep Behaviour Disorder: Delineating Progression Markers from the Sebum Volatilome

DOI: 10.1038/s41531-025-01026-8

Link:

***

Biotechnology is enabling us to find new and more sustainable ways to produce chemicals, materials, and everyday products, by understanding and harnessing nature’s own processes and applying them at industrial scales. Supported by the Manchester Institute of Biotechnology, our 400+ experts are innovating solutions in environmental sustainability, health and sustainable manufacturing. Find out more about our biotechnology research.  

The findings - based on the scans of 1,684 women - could make the difficult task of determining whether labour should be induced in the final stages of pregnancy easier, resulting in fewer complications, say the researchers.

Published today in the Lancet Obstetrics, Gynaecology and Women’s Health, the study was led by gynaecologist Sanne Gordijn of the University Medical Center Groningen (UMCG) in collaboration with Wessel Ganzevoort of Amsterdam University Medical Centre and Professor Alexander Heazell from The University of Manchester.

When pregnant women feel their baby is moving less in the final weeks of pregnancy, they are referred to hospital where an examination is carried out to assess the condition of the baby.

The examination consists of monitoring the baby’s heart rate and an assessment of its growth and amniotic fluid - the fluid around the baby it.

Now the researchers have discovered that an extra ultrasound scan - in addition to the other tests-  is able to significantly help doctors to see whether a baby would benefit from being born earlier.

By measuring the resistance in the blood vessels of the umbilical cord and the baby's brain they were able to accurately assess the functioning of the placenta and the condition of the baby, making it easier to decide if doctors needed to induce delivery earlier.

The perception from mothers that their baby is moving less commonly can occur when a baby has changed position or the mother hasn’t noticed the movement because she is busy or distracted.

However in some cases, reduced movement could be a sign that the baby is unwell, which can be worrying for pregnant women and midwives.

Professor Heazell said: “We know that a reduction in baby’s movements is a common reason to attend maternity services. Thankfully, in the majority of cases the baby is ok.

“The findings of this study will help us to reassure the majority of mothers that their baby is healthy, and help us to focus intervention for the babies who will benefit from being born because they are not receiving enough oxygen or nutrients in the womb.”

Sanne Gordijn said: “We call the ratio between the two ultrasound measurements the Cerebro Placental Ratio (CPR). The idea is that an abnormal value may indicate that the placenta is not functioning properly.

“In that case, it is better for the baby to be born in the short term. We do this by inducing labour. If the value is normal, it would be better to wait for the natural moment of delivery, as the baby may not be completely ready yet. Women who want to give birth at home can still do so.”

“The results of this study show better outcomes for the baby when the result of the CPR measurement is known.

“This means that we see fewer complications during childbirth when this measurement is taken, compared to the current policy where it is not done.”

She added: “If doctors know the results of this measurement, they can better distinguish whether the baby's reduced movement has a harmless cause or whether it requires action.

“This ensures that mother and baby receive the care that best suits their situation.' The guideline on reduced fetal movements will soon be updated; the professional association will incorporate the results of this study into it.”

The study was funded by ZonMw from the Netherlands.

Sanne Gordijn conducted this CEPRA study together with researchers from Amsterdam UMC in 23 hospitals. Laura Lens, the MD, PhD student on this study presented at the international SMFM conference in Denver (USA) and Sanne in London. The study is published on July 10 in the authoritative scientific journal The Lancet Obstetrics, Gynaecology & Women’s Health.

• The study is published in the Lancet Obstetrics, Gynaecology and Women’s Health and is available
• doi.org/10.1016/j.lanogw.2025.100002